The History Of Yeast Glucan

In the 1940s, Dr. Pillemer first discovered and reported a substance in the yeast cell wall that had the ability to enhance immunity. Afterwards, further research by Dr. Diluzio from the University of Toulon revealed that the substance in the yeast cell wall that enhances immunity is a polysaccharide - β - glucan, which was isolated from bread yeast.
It was first discovered in 1963 to have anti-tumor activity, and later it was discovered to have antibacterial and immune regulatory effects. It has unique biological activity in tumor, hepatitis, cardiovascular, diabetes, blood lipid reduction, anti-aging and other aspects.
Yeast glucan was the first glucan discovered to have immune activity.
Research institutions such as Harvard University, Tulum University, Washington University, and the US Air Force Institute of Radiobiology have purified β -1,3-glucan from Agaricus bisporus through fermentation and confirmed that natural yeast glucan has a unique targeting effect, which can selectively clear toxins in the body and increase the phagocytic ability of macrophages by more than 10 times, rapidly achieving optimal balance of the human immune system without any toxic side effects of drugs, effectively preventing the occurrence of various chronic diseases.
On May 20, 2010, the Ministry of Health of the People's Republic of China issued Announcement No. 9 of 2010, which recognized yeast β - glucan as a new resource product.
The active structure of β - glucan is a polysaccharide composed of glucose units, most of which bind through β -1,3, which is the way glucose chains connect. It can activate macrophages, neutrophils, etc., thus increasing the content of white blood cells, cytokinins, and special antibodies, comprehensively stimulating the body's immune system, and having a very good repairing effect on damaged cells. So, the body is more prepared to resist diseases caused by microorganisms. β - glucan can rapidly restore the ability of lymphocytes in injured bodies to produce cytokines (IL-1), effectively regulating the body's immune function.
Numerous experiments have shown that β - glucan can promote the production of IgM antibodies in the body, thereby enhancing the immune function of body fluids. This glucan activated cell can stimulate host non-specific defense mechanisms, so its application in tumors, infectious diseases, and the treatment of trauma is highly anticipated. β -1,3-glucan extracted by special steps from Agaricus bisporus and free of endotoxins has been recognized by the US FDA as a safe substance that can be added to health foods. Many reports have shown that oral administration of yeast β -1,3-glucan to mice can increase the phagocytic effect of strong peritoneal cell antibacterial activity.
Yeast β - glucan is a polysaccharide with enhanced immune activity that exists in the yeast cell wall. β - glucan is widely present in various fungi and plants, such as American Agaricus bisporus, shiitake mushrooms, Ganoderma lucidum, and oats, and is the main functional substance for their health benefits. Yeast glucan has stronger immune enhancing activity and has the effects of improving blood lipids, clearing toxins, resisting radiation, repairing cells, and improving intestinal function.